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S-acylated proteins of SNARE complex, including syntaxin, SNAP25, VAMP2 and synaptotagmin 1 are involved in the synaptic vesicle fusion machinery in neuronal cells (69) and also in pancreatic -cells (70)

These mediators can also be generated through 5-LOX metabolism of 15( S )-HETE, the product of 15-LOX-2 metabolism of arachidonic acid

Collectively, these findings suggest that Epitalon may not function as a traditional sleep aid but rather as an influence on the biological systems that regulate sleep timing and circadian organization

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