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Ohno et al., 2012) ( Figures 2 and 3 )

Interestingly, one study reported that GCN2 is dispensable for T cell anti-tumor activities in murine melanoma models, as T cell-specific GCN2 knockout neither impairs T cell responses against tumors, nor does it significantly affect FoxP3 expression in CD4+ T cells or IFN- expression in both CD4+ and CD8+ T cells in the tumor

Kareyeva AV, Grivennikova VG, Cecchini G, Vinogradov AD

Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice

Support is as per MTR by optimising dietary or supplemented vitamin B12 (especially methyl B12) and zinc as a cofactor
