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The flow rate of 1.0 ml/min was selected to sharpen the peaks, resulting in NAC and Di-NAC retention times of 8.9 min and 23.7 min, respectively

At the intracellular level, it is formed in an amount of approximately 14 M [2], not only deriving from glycolysis but also from the metabolism of ketone bodies, lipids, and the amino acids glycine and threonine (also the decarboxylation of alanine and hydroxylation of taurine) from acetone, hydroxyacetone (acetol), and aminoacetone, respectively

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Kumar S., Pandey A.K

Activated p53 triggers cell cycle arrest to provide damaged DNA with enough time to repair or, in the case of excessive damage, to initiate apoptosis, thus preventing the proliferation of cells carrying severe genetic defects (42, 43)

Wu PL, Wang PS, Gu MY, Xue J, Wu XL