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Rather than canonically activating downstream proinflammatory cytokines, STING promotes autophagic degradation of GPX4, thereby triggering neuronal ferroptosis (Woo et al., 2024)

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However, there are still some difficulties to overcome, such as how to specifically regulate the targets of WSNs in particular brain regions

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PGs are synthesized upon oxidation of arachidonic acid (AA) by PTGS enzymes that contain both the cyclooxygenase and peroxidase functions