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ROS regulation of ABC transporters is a new method to overcome drug resistance in cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Maroteaux L., Campanelli J.T., Scheller R.H

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A first mechanism is the direct interaction with the reducing thiolate, leading to irreversible inactivation of the active site, as described for the inactivation of GSTs (Scheme 9)
