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Iodoacetamide was added to 10 mM and incubated in the dark at room temperature for 30 min to alkylate the proteins

But dogs with digestive disorders or other health issues may not be able to absorb enough of it, and the resulting B12 deficiency can cause serious health problems, including diarrhea, weight loss, and even seizures

Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2

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J Experiment Pharm