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While anyone with a B12 deficiency can benefit from injections, certain groups are more likely to require this treatment, including vegetarians and vegans who may not consume enough B12-rich foods, individuals with digestive disorders like Crohns disease or coeliac disease, those with pernicious anaemia that affects B12 absorption, people recovering from weight loss surgery or other gastrointestinal procedures, older adults whose ability to absorb B12 decreases with age, and individuals experiencing prolonged fatigue or low energy levels

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This suggests that tesofensine may act, in part, by modulating neuronal activity in the LH to reduce food intake and promote weight loss

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Taking too much vitamin B12 can lead to skin rashes, digestive problems, anxiety, and heart palpitations.