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10.3390/pharmaceutics12121185 2 AdebergS.BernhardtD.Ben HarrabiS.BostelT.MohrA.KoelscheC.et al (2015)

Attesting their sensitivity to high-light or methylene blue, these slr0236-sll1545 cells transiently accumulate ROS, and then reduced and oxidized glutathione in that order

Uncarboxylated osteocalcin inhibits high glucose-induced ROS production and stimulates osteoblastic differentiation by preventing the activation of PI3K/Akt in MC3T3-E1 cells

For many experiment, we also used 10 nM of ligand for stimulation, which is a more physiological level than the 100 nM used in many previous experiments

In summary, AST demonstrates promising therapeutic potential in PD by targeting key pathological mechanisms such as oxidative stress, neuroinflammation, and mitochondrial dysfunction