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The incidence of chronic peripheral neuropathy following oxaliplatin treatment has been estimated as approximately 70%, with development of the condition usually occurring at cumulative doses exceeding 540 mg/m 2 (Cersosimo, 2005

10.1016/j.freeradbiomed.2018.09.043 50 IngoldI.BerndtC.SchmittS.DollS.PoschmannG.BudayK.et al (2018)

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Molecular mechanisms of calcium-dependent excitotoxicity

On the other hand, STK38 mediates phosphorylation of RIPK1 at serine 309, which in turn promotes phosphorylation of RIPK1 at serine 166, thus accelerating necroptosis in a primate-specific manner