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Beyond their role as an alternative fuel for the brain, the impact of ketone bodies on neuronal physiology has been highlighted by the use of the so-called ketogenic diets, which were proposed about a century ago to treat infantile seizures

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In human trials, however, the risk for muscle fiber necrosis should be monitored carefully and explored further

The whole process generates several kinds of inflammatory cytokines that induce inflammation and cause apoptosis and necrosis [59]