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It is also produced at extra-gonadal sites including adipose tissue, skin, osteoblasts, osteoclasts, aorta, and the brain

For example, intermittent hemodialysis may be impeded for several weeks owing to pigment distribution across the dialysate membrane with subsequent triggering of a colorimetric alarm designed to detect blood leaks.4 Continuous renal replacement therapy, however, is unaffected

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