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4 Discussion BPD is a severe chronic lung disease primarily impacting preterm infants, for which effective treatments remain lacking ( In vitro , Di-ART-GPC decreased inflammatory factor levels in hyperoxia-exposed macrophages while also elevating GPX4 expression, suggesting that Di-ART-GPC may protect against BPD lung injury by regulating macrophage ferroptosis

Ferroptosis has garnered strong interest due to its therapeutic potential in addressing therapy-resistant and metastasizing cancers, and its involvement in neurodegenerative diseases

Allicin and other functional active components in garlic: Health benefits and bioavailability

Through KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis of the genes identified by positive screening, we found that genes related to the Wnt signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway or encoding ABC transporters, all of which have been reported to play key roles in mediating CDK4/6i resistance, were significantly enriched in the CDK4/6i treatment group (Fig