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In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

These should be treated with your usual medication

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Together, they address both the hormonal and neurological components of sleep disruption

Always inform your healthcare provider if you have allergies to vitamins or any other medications you are taking