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10.1038/s41586-022-05022-3 74 MurphyT
10.1172/jci200318127 16 EbanksB.ChakrabartiL
Figure 5 Zone Specific Metabolism Paracetamol is metabolized in the liver predominantly by CYP enzymes where it is metabolized to the cytotoxic intermediate NAPQI, which in turn depletes glutathione, leading to cell death after an overdose (McCarty et al., Figure 6)
Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells
Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes
