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Description
Criteria for necrosis included karyorrhexis (loss of nucleus) and/or degeneration of cytoplasm with either coagulative or liquefactive changes

Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins
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2001;280:E489-E495 176

In a subsequent group given three 50 g IN doses (1 day before lesioning, 1 h before lesioning, 1 day post-lesioning), lesioned rats had even greater neuroprotective and regenerative effects, showing that multiple smaller doses in short intervals were more effective than a larger single dose [36]
