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Pat No 6,747,009of the formula I: wherein Z=CH 2 and Y=CH 2 , or Z=O and Y=C, R 1 and R 2 are independently selected from the group consisting of H, linear or branched alkyl (1-25C), aralkyl (6-26C), cycloalkyl (6-25C), heterocycles (6-20C), ethers or polyethers (3-25C), and where R 1 -R 2 together have 2-20C atoms and form a macrocycle with the remainder of formula I

CircRNAs often function by sequestering miRNAs, acting as RNA sponges to regulate the expression of miRNA target proteins

Data Availability: All relevant data are within the paper

Vega-Naredo, I., Cunha-Oliveira, T., Serafim, T