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Vitamin A and retinoid signaling: genomic and nongenomic effects

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In the oxidation of these substrates, until they become medium-chain length, the water addition is catalyzed by an enoyl-CoA hydratase activity, the second oxidation step is catalyzed by an NAD + -dependent long-chain hydroxacyl-CoA dehydrogenase activity [long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) activity], and finally the cleavage into an acyl-CoA and an acetyl-CoA is catalyzed by a thiolase activity

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Furthermore, the authors observed higher fat stores in wild-type worms grown on OP50 compared to HB101, consistent with results presented in this study