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doi: 10.3389/fmolb.2025.1699492 Received 06 September 2025 Revised 25 December 2025 Accepted 30 December 2025 Published 26 January 2026 Volume 12 - 2025 Edited by Konstantinos Zarbalis, University of California, Davis, United States Reviewed by Silvana Patio-Cardona, University of Castilla La Mancha, Spain Remi Fritzen, University of St Andrews, United Kingdom Updates Copyright 2026 Wu and Fang

NLR, Nucleotide-Binding Domain and Leucine-Rich Repeat Receptor

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Reduced butyrate production in dysbiotic non-obese diabetic (NOD) mice, has been associated with increased colon permeability, increased production of reactive oxygen species (ROS) and pro-inflammatory cytokines like IL-1beta