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[2] Some individuals do experience gastrointestinal side effects when taking B12 supplements, particularly when first beginning supplementation
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Men currently on TRT who wish to maintain testicular function and preserve future fertility option can use the stack at lower doses

The Journal of cell biology 2013;203, 929-942, doi:10.1083/jcb.201306073 28

About 1 in 10 people aged 55 years and over are affected by PN, and the most common cause is diabetes