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The body has already adapted to substantial receptor activation

Since diagnosis, the median (range) duration of the disease, motor fluctuations and dyskinesia was 7.9 years (3.712.2 years), 4.3 years (1.28.3 years) and 2.4 years (0.25.3 years), respectively, with very high dopa sensitivity (median: 78.9%

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Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats

[DOI] [PubMed] [Google Scholar] 15.Hanisch F., Toresson L., Spillmann T