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[DOI] [PubMed] [Google Scholar] 149.Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, Antel JP

The importance of the carnitine shuttle is underscored by the report that a polymorphism of the CPT II gene that leads to decreased enzyme activity may be associated with acute encephalopathy associated with influenza [58, 59] and that deficiency of the OCTN2 transporter can lead to neurological manifestations including cognitive impairment and seizures [51]

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doi: 10.1016/j.jnutbio.2012.06.012

This condition occurs when the dietary intake of ALA is too low in comparison with linoleic acid (LA, C18:2- 6) and the ratio 6/ 3 is higher than 5/1