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Vitamin B12, or cobalamin, is a water-soluble vitamin

Dev Biol 229 : 141162 Dominici FP et al

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This increase in blood volume can cause swelling

Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)