fda status bpc-157 approval RFK Jr pushes for of peptide | Eric Topol, MD posted on the topic BPC-157: The Real Reason Why

Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism

Bergami M, Santi S, Formaggio E, Cagnoli C, Verderio C, Blum R, Berninger B, Matteoli M, Canossa M

Molecules that have vitamin B12 are called cobalamins because they contain cobalt

Nat Genet 41:216220

Using the free base can lead to non-uniform suspensions, inaccurate dosing, and lower-than-expected plasma concentrations, directly compromising the integrity of pharmacokinetic and pharmacodynamic studies that rely on the published clinical trial data established with the phosphate form