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By inhibiting NNMT, 5-Amino-1MQ preserves nicotinamide availability for conversion to nicotinamide mononucleotide (NMN) via the enzyme nicotinamide phosphoribosyltransferase (NAMPT), which then converts to NAD+

16-week on / 4-week off: Extends into the range of the Phase IIb trial duration while building in a recovery window

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

Iron infusions are medical procedures used to deliver iron directly into the bloodstream

" Vitamin B12 deficiency shows up as fatigue, weakness, pale skin and breathlessness