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They also demonstrated that ferroptosis occurs in a synchronized manner in renal tubules and eventually causes the failure of entire functional units

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Genetic studies often suffer from small effect sizes, phenotypic heterogeneity, and population stratification, limiting reproducibility across diverse cohorts

Best et al similarly reported positive effects of RT on white matter structure, demonstrating a reduced rate of white matter atrophy in individuals in the RT group compared to controls after the 1-year training intervention as well as 1 year post-intervention ( Effects of resistance exercise training on cognitive function The effects of acute and habitual exercise of any type on cognitive function are well established, with multiple quality reviews highlighting the effectiveness of resistance exercise on improved cognition across multiple domains (Landrigan et al., 2020

Functional Neuroimaging Functional neuroimaging techniques, notably positron emission tomography and functional magnetic resonance imaging (MRI), have significantly advanced our understanding of the central mechanisms underlying neuropathic pain, including both spontaneous and provoked forms, although their use remains limited to preclinical studies rather than clinical diagnosis [255]