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The Outcome of Patients (pts) with Chronic Myeloid Leukemia (CML) Treated with Imatinib Outside of a Clinical Trial or On a Clinical Trial At a Single Institution

Unlike traditional protonophore uncouplers such as carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP), BAM15 and niclosamide, SR4 belongs to a newly defined class of fatty acid-activated proton transporters that facilitate the translocation of fatty acid anions across the mitochondrial inner membrane, inducing controlled proton leak and mitochondrial uncoupling (15,16)

And this is what's challenging, too

CKD is more common in older cats and has a gradual onset

It may also be used for the vitamin B12 absorption test (Schilling test)