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The p.R778L mutation affects transmembrane transport of copper while p.G943S and p.M769V mutations result in defective copper metabolism but preserved ceruloplasmin levels

Recently, by using the SPEAC technique with co-culture of cells in drops and CRISPR-Cas induced genetic manipulation, Wheeler and collaborators (153) identified the amphegulinIL33-ST2 pathway as another communication mechanism between microglia and astrocytes, relevant to the pathogenesis of MS

PMID: 106 DongQHanZGaoMTianL

Rainbolt, T

Subsequently, the exterior of siRNA/ADC-AuNP is tiled with aptamer-incorporated Y-shaped backbone-rigidified triangular DNA bricks (Ap-YTDB) by hybridization with the terminal complementary fragments of ADCs, generating CS-type siRNA-encapsulated vehicles, siRNA/Ap-CS