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Pregnancy and lactation: Maintaining normal vitamin B12 levels is especially important for pregnant and breastfeeding women, as low levels can affect fetal development and lead to developmental delays in breastfed babies

Allergic Reactions and Anaphylaxis In rare cases, more severe allergic reactions can occur

NNMT inhibition in cell culture models has been associated with enhanced myogenic commitment, suggesting that the same NAD+/SAM preservation mechanism that restores adipocyte energy expenditure may also support muscle regeneration processes

PLoS ONE 6 , e26223 (2011)

How Long Does It Take for Vitamin B12 Supplements to Work