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Compared to mice conditioned with cyclophosphamidean established conditioning agent, all ADC-treated mice showed similar or superior engraftment by 8 weeks, highlighting the potential of this regimen

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Glutamate-cysteine ligase (Gcl) is the rate-limiting enzyme in GSH synthesis and condensing glutamine and cysteine into -glutamylcysteine, which is then combined with glycine in a reaction catalyzed by GSH synthase to form GSH 10
