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This is of great significance for improving enrollment criteria in clinical trials, quantifying efficacy indicators, and achieving treatment personalization
however, supplementation with high doses of carotenoids such as -carotene did not reduce the risk of chronic diseases
This means that the activation of STAT3 signaling, e.g., through the insulin/IGF-1 pathway, is able to stimulate pro-inflammatory/pro-tumorigenic signaling in the host tissue
