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This redox activity of Fe is crucial for enabling CAT-like activity and other antioxidative activities in scavenging ROS

Cisplatin-induced extracellular-signal-regulated kinase (ERK) activation precedes p53-mediated DNA damage response since ERK directly phosphorylates p53 causing up regulation of p21, 45kd-growth arrest and DNA damage (GADD45), and mouse double minute 2 homolog (Mdm2) (DeHaan, Yazlovitskaya et al., 2001).Thus, activation of ERK may cause cell cycle arrest allowing time for the repair of cisplatin-induced DNA damage via p53

Hopefully getting better

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