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Interestingly, they showed that in the distal colon IL-18 signaling occurs directly with goblet cells but, in the proximal colon this signaling is indirect, suggesting the involvement of other cell types in this signaling cascade

These effects are mediated by the secretion of IL-10, TGF-, VEGF and EGF (71, 73)

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The evidence breaks down along predictable lines, and being clear about what each tier shows is important

We note that if we divide the observed and model trends by the global mean trends and follow the procedure above to adjust the ensemble spread, the magnitude and uncertainty scaling factors change, but the signal-to-noise ratios remain constant