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BBB opening can increase the local concentration of therapeutic agents in the brain without damaging normal tissue, and via FUS-BBB opening to enhance CNS penetration of AD-treated therapeutic agents is an attractive approach
doi: 10.3389/fphar.2018.00721 54 FrstermannUXiaNLiH
this happens in compensation for the reduced activity of myeloid cells (Kotoda et al., 2018)
Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation
