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In some in-vitro studies, fibroblast cultures exposed to AHK-Cu complexes appeared to show an increase in collagen type I production, with reports of increases as high as 300% over controls

Western Orthopaedic Assosiation

doi:10.1016/j.ctim.2018.09.015

In general, these two anabolic hormones tip the scale towards bone formation and mineral acquisition, but in excess, they can stimulate bone resorption and impair bone remodeling

Its also difficult to treat because TMD can have a number of causes that require different forms of treatment
