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Concurrently, NAC prevents behavioral deficits in mice by inhibiting microglial activation (Lehmann et al., 2019)

This imbalance may explain why GPX2 inhibition does not reduce the expression of chemoresistance genes

Combining this result with the structural similarity of N-120 to the PapD-like family of chaperones suggests that this domain may be involved in stabilizing or enhancing the solubility of the Mac-1 domain

Conversely, when one of the components of iron uptake, storage, utilization and efflux is interfered [29], such as increased degradation of ferritin induced by nuclear receptor coactivator 4 (NCOA4) or inhibition of the iron export protein SLC40A1 [30, 31], intracellular iron homeostasis will be affected

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