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Used by every cell and tissue in the body, glutathione plays an important part in many physiological processes: boosts the action of other antioxidants supports nutrient metabolism supports immune response facilitates processes that neutralize drugs, chemicals, metabolic waste, and other toxins A deficiency of glutathione contributes to oxidative stress which plays a key role in aging and the development of diseases such as cancer, Alzheimers disease, Parkinsons disease, cardiovascular diseases, and respiratory conditions, to name a few

Network beyond ido in psychiatric disorders: revisiting neurodegeneration hypothesis

For instance, GSH can be depleted, through inhibition of its synthesis using an inhibitor of GCL (buthionine sulfoximine, BSO) (57) under conditions that maintain the intracellular cysteine pool intact,

doi:10.1093/brain/120.7.1139

2020 Aug 15;45(16):E1020-E1025