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References 1 ReinherzELKungPCGoldsteinGLeveyRHSchlossmanSF

Cyanocobalamin is a form of vitamin B12 used to treat or prevent B12 deficiency, which can result from dietary limitations, certain types of anemia, pregnancy, gastrointestinal disorders, or other medical conditions

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Kishis investigation tested stroke-prone spontaneously hypertensive rats and was able to conclude that caloric restriction, in addition, to exercise up-regulated BDNF in the hippocampus leading to synergetic protection against cognitive decline