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Tumor necrosis factor-alpha (TNF) production is increased in adipocytes from obese individuals and may contribute to enhanced basal lipolysis in obesity (97, 104, 105)

In vivo dosing relies largely on intraperitoneal administration and exposure profiles that differ from oral human use, and interspecies differences in mitragynine metabolism and elimination complicate dose extrapolation

doi: 10.1161/01.RES.0000252802.25497.b7 192 FordIDouglasCPrestonFLawlessAHamptonK
