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We assessed the pattern of indels using the COSMIC ID83 classification, which considers size, nucleotides affected, and presence on repetitive and/or microhomology regions, and did not find obvious differences (Fig

doi: 10.1089/ars.2005.7.813

KW-6356 is a second-generation A2A antagonist which has shown positive results with regard to motor progression in early-stage PD, as assessed by changes in the MDS-UPDRS motor score from baseline until the end of follow-up, both in combination with levodopa (NCT03703570) and as monotherapy (NCT02939391, Table 2) (Chen et al

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