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These findings indicate that while some individuals may observe changes within weeks, the effects are typically minimal and temporary

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A similar mechanism has been described for the prion protein PrP, wherein its mislocalization to the cytosol enables aberrant binding to cytosolic ubiquitin ligase, sequestering the enzyme and reducing its functional availabilitythereby contributing to neurodegeneration 82

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Major Guidelines from Professional Societies for the Diagnosis and Management of Endometriosis-Related Pain and Infertility* (7) , (21) , (28) : * Guidelines are from the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology