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Approval for biopsy procurement from new-onset type 1 diabetes donors was granted by the Norwegian Governments Regional Ethics Committee following informed consent

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Statements Acknowledgments The authors thank Jose Santiago and Mich Beales for critical review of the manuscript

Cys94 and Cys99 are located within the zinc tetrathiolate cluster (Erwin et al., 2005) that is important for the eNOS dimer interface

Comprehensive studies of the molecular changes that occur with aging across multiple organs in mice have identified unique molecular aging trajectories and timings 1,2,3,4 , and susceptibility and resilience to diseases of aging in specific organs such as the brain, heart and kidney varies substantially across the population 6