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The method is based on the assumption that the presence of damage in the DNA structure, such as double- and single-strand breaks, modified bases, or their adducts, will hinder the activity of DNA polymerase and decrease the efficiency of the reaction [7]

Shapiro, R.E

This differential tissue regulation of these enzymes results in increased BCAAs in adipose tissue, a decrease in liver BCAAs and no change in skeletal muscle

& Dinis-Ribeiro, M

The etiologies of five congenital hypothyroid patients were unknown because these patients did not show positive test results for thyroid radionuclide uptake, thyroid sonography, or serum thyroglobulin, although they were kept on regular LT 4 therapy