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We and others have performed SAR optimization and synthesized prodrugs of analogs to target M
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Thats a different layer of the cellular machinery than most other longevity tools
HDAC9 overexpression in forebrain glutamatergic neurons preserves cognitive function in aged mice Given that HDAC9 expression decreases with aging in the PFC and hippocampus, and HDAC9 knockout results in cognitive impairments, we sought to determine whether HDAC9 overexpression could ameliorate age-related cognitive decline
