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208 In 2016, the pyrazole compound 8 (APX-115 also known as Ewha-18278) was reported as a pan-NOX inhibitor ( K i of 1.08, 0.57, and 0.63 M for NOX1, NOX2, and NOX4, respectively) with no activity on xanthine oxidase or glucose oxidase
[DOI] [PubMed] [Google Scholar] 26.McArdle F., Rhodes L.E., Parslew R., Jack C.I., Friedmann P.S., Jackson M.J
In collagen, lysine residues are oxidized by lysyl oxidase to form aldehyde groups, which contribute to cross-linking structures
Carretero and colleagues have also shown that increased GSH promotes growth of metastatic melanoma cells in the liver (Carretero et al., 1999)
