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Despite their effectiveness, they face limitations such as high costs, complex data interpretation, sensitivity and specificity issues, limited spatial resolution, and restricted coverage to known CpG sites, offering limited insights into the underlying mechanisms of methylation (57)

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However, further investigations are warranted to elucidate the mechanism by which vitamin C counteracts apoptosis in alveolar type II epithelial cells as well as its impact on apoptosis in other lung cell types

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