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Indeed, the regulatory effects of curcumin on the first- or second-stage metabolisms of AFB1 involve the regulation of the activities or expressions of CYP450s (i.e., CYP1A1 and CYP2E6), Nrf2-mediated II metabolizing enzymes or products (i.e., GST isozymes and GSH), and P-gp, which may be considered a critical molecular mechanism for explaining its protective effects on AFB1-induced toxicity

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N= 1,169, median serum level = 30 ng/ml or 75 nmol/L)

354 Feng et al