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Schaffner noted that experts had been unsure whether the shot, designed to target the original variant, would work against BA.4 and BA.5

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For the treatment policy estimand, continuous endpoint analyses were conducted with the use of the analysis-of-covariance method, with randomized treatment as a factor and baseline endpoint value as a covariate

The use of sdAbs such as [ 68 Ga]Ga-NOTA-Nb1053 allows same-day imaging one hour after injection with high target-to-background ratios, avoiding concerns associated with non-specific bone accumulation seen with 89 Zr-labeled mAb immunoPET techniques