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Keywords: L-carnitine, acetyl-L-carnitine, neuroprotection, neonatal hypoxia-ischemia, pediatric traumatic brain injury, metabolism, inborn errors of metabolism, carnitine shuttle Introduction L-Carnitine is a naturally occurring compound found in most, if not all, mammalian tissues including brain [1]

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The heart, skeletal muscle, and adipose tissues have an increased demand for carnitine during strenuous exercise or metabolic stress, at which point the liver and kidney adjust carnitine synthesis and reabsorption accordingly in response to the changing demands of these tissues