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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

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(2016) utilized the plasma-free amino acid dose-response method to compare the bioavailability of methionine in Smartamine M versus Mepron, finding that Mepron had 28% of the bioavailability of Smartamine

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