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Comorbid conditions, such as diabetes and chronic kidney disease, amplify ketamines neurotoxicity by increasing oxidative stress and impairing drug metabolism

Likewise, HCV viremia persists in other organ transplant recipients with pre-transplantation infection and may result in rapid progression of liver disease in those with advanced fibrosis168

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Pharmacokinetics and mechanism of action of detoxifying low-molecular-weight thiols

Although generally safe when used at recommended dosestypically around 2-5 mg/kg/daysome patients may experience minor side effects